Endothelial Induction of the T-Cell Chemokine CCL21 in T-cell Auto-Immune Diseases Running Head: CCL21 in T-cell Auto-Immune Diseases
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Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases.
The signals that mediate T-cell infiltration during T-cell autoimmune diseases are poorly understood. The chemokine CCL21 (originally isolated by us and others as Exodus-2/6Ckine/SLC/TCA4) is highly potent and highly specific for stimulating T-cell migration. However, it is thought to be expressed only in secondary lymphoid organs, directing naive T cells to areas of antigen presentation. It is...
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